Nasal steroid use and osteitis development in chronic rhinosinusitis with nasal polyps

Abstract Objectives Osteitis and tissue remodeling are inflammatory processes associated with the severity of chronic rhinosinusitis nasal polyps (CRSwNP). Nasal steroids mainly recommended therapeutics in treatment disease, besides their beneficial effects, they may worsen osteitis via osteopenia. This study aimed to search for coalescence CRSwNP steroid use (NSU). Methods A cross-sectional was designed. Patients who underwent paranasal sinus computed tomography (PNSCT) imaging were queried, sino‐nasal outcome test-22 (SNOT-22) completed. Regular NSU defined as a continued 2 months last 6 months. The cumulative period during determined classified no or, 1 3 months, or more than Lund-MacKay scores (LMS) Global Scores (GOS) calculated 10 sinuses PNSCT. Results Sixty-two patients included study. mean GOS score 5.7 ± 1.7 points higher regular ( p = 0.002, 95% CI : 9.2–2.2, t -test). LMS SNOT-22 also significantly 0.036 < 0.001 consecutively). showed significant increase according 0.001, one-way ANOVA test). Similarly, duration total NSU. positive high correlation r 0.608 0.753 Conclusions association found between is probably due disease. However, it question value effect development osteitis. presence should be investigated future histopathological studies. Level evidence IV